1. Vizel' A.A., Fakhrutdinova I.D. New aspects of using integral rheography of the body in phthisiopulmonological practice // Probl. Tuberk., 1985. Vol.6. P.2527.
Forty-six patients with acute tuberculosis of the lung were examined. It was shown that the coefficient of respiration changes in the blood stroke volume evaluated be the reorgam, the vital capacity of the lungs, and the number of the affected segments were statistically conjugated. This allowed deriving the linear regression equations providing with the use of the integral reograms estimation of the volume of the pulmonary lesions and vital capacity expressed as s percentage of the normal.
PMID: 4048120 [PubMed - indexed for MEDLINE]
2. Krasnoperov F.T., Vizel' A.A., Fakhrutdinova I.D., Guryleva M.E. Hemodynamics of the systemic circulation and pulmonary ventilation in pulmonary tuberculosis // Sov. Med., 1986. Vol. 1. N.71-73.
PMID: 3961572 [PubMed - indexed for MEDLINE].
No abstract.
3. Vizel A.A., Fakhrutdinova I.D. Hemodynamics of the lesser and greater circulation in patients with pulmonary tuberculosis // Probl Tuberk., 1986. N 3. P.2125.
(Hemodynamics of pulmonary and systemic circulation in patients with pulmonary tuberculosis).
Combined functional examination of 83 palients with pulmonary tuberculosis and 28 healthy persons showed that there was uniform impairment of the systemic hemodynamics in the patients with different localization of the process in the lungs. When both the lungs were affected the decrease in the volume blood flow was the highest, the reopulmonograms were deformed and the precapillar vascular tension was increased. In the patients with unilateral tuberculosis impairment of the hemodynamics in the affected lung and compensatory redistribution of the blood flow in the unaffected lung were observed.
PMID: 3714687 [PubMed - indexed for MEDLINE]
4. Vizel' A.A. Clinico-functional characteristics of infiltrative pulmonary tuberculosis // Vrach. Delo, 1986. N 8. P.5759.
A study of 61 patients suffering from infiltrative pulmonary tuberculisis compared with 28 healthy persons indicates that this form of pulmonary tuberculosis is accompanied mainly by the obstructive type of disorders of the breething mechanics and a corresponding proportional alteration of the systemic hemodynamics. More than '/3 of patients showed concomitant pathology hypertensive disease, ulcer, chronic bronchitis, lung cancer, alcoholism.
PMID: 3776163 [PubMed - indexed for MEDLINE]
5. Vizel A.A., Papkova I.N. Analysis of the causes of death in patients with pulmonary tuberculosis // Probl. Tuberk., 1987. N 2. P.46-48
Ninety six lethal outcomes in inpatients with respiratory tuberculosis were analysed. It was shown that tuberculosis progress leading to pulmonary and cardiac insufficiency was the most frequent cause of the lethal outcomes. Then followed pulmonary haemorrhage and extrapulmonary factors. The role of concomitant pathology especially chronic nonspecific diseases of the lungs, cardiological and oncological diseases was also significant. Possible avenues to decreasing the death rate are indicated.
PMID: 3575280 [PubMed - indexed for MEDLINE]
6. Vizel' A.A., Fakhrutdinova I.D. Zonal rheopulmonography and Bergan's lateral test in preoperative examination of patients with respiratory diseases // Grudn. Khir., 1987. N 4. P.93.
PMID: 3623212 [PubMed - indexed for MEDLINE]
No abstract.
7. Krasnoperov F.T., Vizel' A.A., Guryleva M.E. Functional status of the liver and volumetric hepatic blood flow in patients with tuberculosis of the respiratory organs // Probl. Tuberk., 1987. N 7. P.5357.
Biochemical indices and liver rheograms of 83 patients with pulmonary tuberculosis were studied. Correlation between the serum bilirubin levels, volumetric hepatic blood flow and treatment terms was shown. Increasing activity of alanine aminotransferase was associated with combined use of isoniazid and rifampicin. Various hepatic disorders in the tuberculous patients were due to various factors and required differential treatment.
PMID: 3658968 [PubMed - indexed for MEDLINE]
8. Egurnov N.I., Vizel' A.A., Perlei V.E., Dundukov N.N. Effect of nitroglycerin on hemodynamic indices and respiration in patients with pathology of the respiratory organs // Probl. Tuberk., 1988. N 2. P.4752.
Forty-four patients with pathological processes in the respiratory organs and 15 healthy persons were examined. It was shown that nitro-glycerin had a favourable effect on pulmonary hemodynamics and ventilation, lowered the stroke volume and systemic arterial pressure. Tetrapolar chest rheography provided results close to those of echocardiography, whereas integral body rheography proved to be useless in estimating the nitroglycerin effect on the heart pumping function because of the specific action of peripheral blood flow on its formation. Without pharmacological influence all the three methods were of an equal informative value.
PMID: 3131758 [PubMed - indexed for MEDLINE].
9. Vizel' A.A. Effect of various broncholytics on bronchial patency and central hemodynamics in patients with pulmonary tuberculosis and other lung diseases // Probl. Tuberk., 1988. N 9. P.2731.
Fifty six patients with pulmonary tuberculosis and chronic nonspecific diseases of the respiratory organs (CNDRO) were examined. Before and after the use of berotec, atrovent, berodual euphylline, beclomet and combination of corinfar and berotec the patients were subjected to pneumotachography and tetrapolar chest rheography. The patients treated with the combination were additionally subjected to ECG and rheopulmonography. On the whole 152 pharmacological tests were performed. Berotec proved to be the most efficient bron-cholytic. However, the other drugs and their combinations, except beclomet may be also recommended as drugs of choice in arresting bronchospasm in patients with tuberculosis and CNDRO. In the patients treated with corinfar and euphylline there were observed concomitant favourable hemodynamic effects. It is indicated that choosing of broncholytics should be individual.
PMID: 3231618 [PubMed - indexed for MEDLINE]
10. Vizel' A.A., Iaushev M.F. Functional characteristics in infiltrative, disseminated and fibrous-cavernous tuberculosis of the lungs // Sov. Med., 1990. N 6. P.119120.
No abstract.
PMID: 2396115 [PubMed - indexed for MEDLINE]
11. Vizel' A.A. Determination of the status of central hemodynamics using the method of tetrapolar thoracic rheography // Probl. Tuberk., 1990. N 8. P.66-68.
No abstract.
Publication Types: Review. PMID: 2255706 [PubMed - indexed for MEDLINE]
12. Vizel A.A., Iaushev M.F. Effects of salbutamol and aspirin on pulmonary ventilation and hemodynamics in patients with infiltrative tuberculosis // Probl. Tuberk., 1991. N 5. P.29-31.
External respiratory function, central and pulmonary hemodynamics and PaO2 were studied in 30 infiltrative tuberculosis patients in the absence of dissemination signs after a single and course administration of aspirin and inhalation of 2 doses of salbutamol. It was found that aspirin had a potentiating influence on the broncholytic effect of salbutamol and was responsible for the prevention of intrapulmonary shunting in the presence of bronchial dilatation.
PMID: 1924238 [PubMed - indexed for MEDLINE]
13. Vizel A.A., Yaushev M.F. Acute test with phinoptin in patients with chronic respiratory incompetence in pulmonary tuberculosis // Kazan Medical Journal, 1996. N 9. P.246248.
40 patients with pulmonary tuberculosis were examined against the background of acute test with phinoptin inhalation in comparison with 11 patients against the background of euphylline inhalation. The moderate broncholithic effect without rough effect on hemodynamics was noted. Phinoptin affected the spi-rographic indexes less but the expiration flows more than euphylline. The authors determined the perspective of the use of phinoptin in chronic forms of tuberculosis and in elderly patients as a corrector of bronchial permeability.
14. Vizel A.A. Use of dimephosphon for correction of functional disorders of external respiration in pulmonary tuberculosis // Sov. Med., 1991. Vol.9. P.6062.
No abstract. Publication Types: Clinical Trial.
PMID: 1798928 [PubMed - indexed for MEDLINE]
15. Vizel' A.A., Belilovskii E.M., Sokolov N.G., Galkov E.M. Optimization of the interpretation of the functional parameters of external respiration // Probl. Tuberk., 1991. Vol.4. N.55-57.
The attempt was made to present the existing criteria of spirogram assesment in the form of a table which has been tested as a program on a personal computer and on a spirograph with microprocessor.
PMID: 1852746 [PubMed - indexed for MEDLINE]
16. Vizel A.A., Galkov E.M., Iaushev M.F., Radchenko S.V. Use of computer technology for teaching phthisiology and pulmonology at medical institutes // Probl. Tuberk., 1992. N 5-6. P.14-16.
The experience of computer technology application at the Phthisiology Department of the Kazan Medical Institute over the last 5 years was generalized. Four classes of the teaching programs were described: program control of the accumulated experience, diagnostic search, a mathematical model of an emergency situation and expert medical systems. Preference is given to the latter two types of programs. It is emphasized that application of the IBM-compatible systems as the most prevalent in clinical practice is promising. Description of the specific programs is presented.
PMID: 1409504 [PubMed - indexed for MEDLINE]
17. Guryleva M.E., Vizel' A.A. Statistical analysis of liver dysfunction in patients with pulmonary tuberculosis using the data base control system // Probl. Tuberk., 1993. N 3. P.3637.
A program HEPATOX has been devised for the study of the frequency of hepatic dysfunction signs within the system of data base control FoxPro. The analysis of the data available for 377 tuberculous patients showed a more important role of the laboratory diagnosis compared to clinical symptoms, a predisposing role of prior hepatitides and active inflammation in the onset of hepatic dysfunction in conditions of on-going chemotherapy. The authors present the frequency spectrum for clinical and laboratory findings from tuberculous in patients with liver dysfunctions. The efficacy of computers in phthisiopulmonology is demonstrated.
PMID: 7984588 [PubMed - indexed for MEDLINE]
18. Vizel A.A. Functional diagnosis in pulmonology // Probl. Tuberk., 1995. N 1. P.4648. PMID: 7761383 [PubMed - indexed for MEDLINE]
No abstract.
19. Vizel A.A., Iaushev M.F., Mustafin R.R., Goncharova L.V. Broncholytic activity of dose-adjusted aerosols in active respiratory tuberculosis // Probl. Tuberk., 1995. N 2. P.7-9.
Spiro- and pneumotachography performed after test of broncholytics atrovent, berotec, berodual and ditec showed these drugs to be effective both in respiratory tuberculosis and chronic nonspecific pulmonary diseases.
PMID: 7777469 [PubMed - indexed for MEDLINE]
20. Arslanov Sh. Sh.,. Vizel A.A., Galiullin A.N.,. Guryleva M.E Tuberculosis epidemiologic situation analysis in Tatarstan for 1980-1984 and 1990-1994 // Kazan Medical Journal, 1996. N2. P.8183.
The comparative analysis of the basic medical statistical indices of tuberculosis for 2 five-years is given. The investigation results show the sharp change for the worse of the epidemiologic situation, and the revealed tendencies are indicative of the real possibility of the subsequent worsening up to the tuberculosis epidemic. The real way out of the established situation is the centralixed interdepartmental program directed to the realization of urgent measures against tuberculosis.
http://www.kcn.ru/tat_en/science/kazmed/km-n2.htm#c1
21. Vizel' A.A., Arslanov Sh.Sh., Iaushev M.F., Shpaner I.Ia., Van'kova E.I., Goncharova L.V., Ibragimova G.A., Ziganshina Z.Z., Guryleva M.E. Medico-social characteristics of inpatients with pulmonary tuberculosis // Probl. Tuberk., 1996. N 3. P.1618.
A questionnaire survey of 103 patients with active tuberculosis of the respiratory organs provided evidence on social factors contributing to more frequent onset of destructive tuberculosis, complications, discharge of M. tuberculosis, associated chronic bronchitis and ulcer. These were: serving sentence in prison or reformatory, poverty, alcoholism. X-ray diagnosis of tuberculosis provided earlier detection of the disease reducing the number of complications and invalidity.
PMID: 8754868 [PubMed - indexed for MEDLINE]
22. Vizel A.A. On the rightness of the use of rifampitsin in the diseases of nontuberculous etiology // Kazan Medical Journal, 1998. N 6. P. 449.
No abstract.
http://www.kcn.ru/tat_en/science/kazmed/km86.htm
23. Vizel' A.A., Ozol S.M., Guryleva M.E., Gizatullina E.D. Antibiotic sensitivity of pathogenic microflora: data of the bacteriological laboratory at the antituberculosis clinic // Probl. Tuberk., 1998. N 4. P.4851.
A total of 426 cultures for nonspecific organisms, made at the Bacteriological Laboratory of the Antituberculosis Dispensary, were analyzed. Escherichia coli, Streptococcus pyogenes, and Staphylococcus aureus were most common among the isolated pathogens. Evaluation of antibiotic sensitivity by using the disks showed augmentin, cefuroxime axetil, and ciprofloxacin to be most effective. Streptomycin and rifampicin resistance of pathogens was highest. In patients with tuberculosis, the non-tuberculosis flora showed resistance to the drugs widely used in general practice (ampicillin, carbenicillin, oxacillin, lincomycin, erythromycin). Among macrolides, rovamycin was more effective than erythromycin. It is concluded that when wide-spectrum antibiotics are prescribed, new and potent drugs should be used in a tuberculosis hospital.
PMID: 9771042 [PubMed - indexed for MEDLINE]
24. Sukhov V.M., Kuynin A.S., Chemichova N.S., Vizel A.A. Validity and efficiency of Ingacort treatment of patients with chronic obstructive br // Kazanskij medicinskij zurnal, 1998. Vol. 79, N 2. P. 9293.
As many as 42 patients with chronic obstructive bronchitis, 24 men and 18 women were treated with Ingacort during 8 weeks. 30 patients with clinical signs of lower respiratory ways infection were given Asitromicin (Sumamed) for 5 days. All patients were divided into two groups depending on age and duration of the disease. Ingacort is recommended as a basic therapy for patients with chronic obstructive bronchitis.
25. Vizel' A.A., Vankova E.I., Ozol S.M., Tagirova D.I. Antibacterial drug of fluoroquinolone series ciprofloxacin // Kazanskij medicinskij zurnal, 1998. Vol.79, N 1. P. 70-73.
No abstract.
26. Vizel' A.A., Khabibullin K.A. Comparative effects of acute tests using ventolin, ventodisk and intal plus in the ambulatory pulmonological practice // Probl. Tuberk., 1999. N 2. P.3537.
In the outpatient setting, 108 patients with obstructive respiratory diseases were examined. They were divided into 3 equal groups which underwent acute ventolin, ventodisk, and intal plus tests. There were no differences in the frequency and magnitude of effects of the three agents as evidenced by the forced expiration flow-volume curve. At the same time albuterol insufflation through a disk-haler (ventodisk) caused powder irritation in some cases, those occurred less frequently with intal plus inhalations. It is concluded that ventolin or intal plus may be the drugs of choice in acute attacks of bronchospasm.
PMID: 10420748 [PubMed - indexed for MEDLINE]
27. Vizel A.A., Gizatullina E.D., Khamitov R.F., Khasanova Sh. M., Fatkullina R.Sh., Filatova M.S., Aznabaeva Yu.A., Khalfiev I.N. Efficiency of ambrosan in bronchopulmonary diseases // Kazan Medical Journal, 1999. N3. P. 179183.
As many as 137 patients with acute and chronic bronchitis, pneumonia, bronchial asthma, bron-choectatic disease and tuberculosis were given ambrosan in a dose of 30 mg three times per day in combined therapy (all patients were given antibacterial drugs). It was shown that ambrosan softens cough, promotes sputum passage, positively affects rhe bronchopul-monary disease course. This effect was the most pronounced in acute and chronic bronchitis (87% and 94,8%).
http://www.kcn.ru/tat_en/science/kazmed/km93.htm#k6
28. Slabnov Iu.D., Vizel' A.A., Cherepnev G.V., Firsov O.V., Sabirova L.A. Use of systemic immunomodulator xymedone in distructive pulmonary tuberculosis // Probl. Tuberk., 2000. N 3. P.2832.
The study was undertaken to examine 59 patients with destructive pulmonary tuberculosis who had T-cell dysfunction (loss of CD3+, CD4+, lymphocytes, slightly positive tuberculin test) and augmented IgA and IgG production. Oral Xymedone given in a dose 2.0 g daily for two 2 months in combination with antibacterial therapy abolished lymphopenia, restored CD4+ counts, CD4+/CD3+ ratio, upregulated IgG levels, but did not affect IgA levels. The Xymedone-treated patients developed fewer side effects due to basic antibacterial chemotherapy and showed more rapid culture conversion, resolution of pulmonary infiltration and closure of destructive cavities.
PMID: 10900981 [PubMed - indexed for MEDLINE]
29. Bender S.B., Vizel A.A. Current approach to the treatment of acute bronchial asthma // Ter. Arkh. (Mosk), 2000. Vol.72, N 8. P.10-12.
AIM: To evaluate the results of nebulised berodual solution in comparison with intravenous euphylline in the treatment of acute bronchial asthma (BA). MATERIAL AND METHODS: The trial entered 73 patients with an acute episode of BA: 22 treated with intravenous euphylline and 51 treated with nebulised berodual solution. Spirometry was conducted and peak expiratory flow rate, heart rate (HR), blood pressure were measured before and after the treatment. RESULTS: The attack was arrested in all the patients who had inhaled nebulised berodual solution. No side effects were registered. Intravenous therapy of euphylline produced only partial bronchodilation in most of the patients and increased HR by 23.4%. CONCLUSION: Berodual nebulised solution is clinically superior to intravenous euphylline in acute BA.
Publication Types: Clinical Trial. PMID: 11019417 [PubMed - indexed for MEDLINE]
30. Vizel A.A., Valieva L.V., Guryleva M.E., Dmitriev E.G. The comparison of flow-volume curve parameters in patients with pulmonary sarcoidosis and COPD // Klin Med (Mosk), 2001. Vol.79, N 10. P.2730.
62 patients with respiratory sarcoidosis (RS) and 50 patients with chronic nonspecific pulmonary diseases (CNSPD) inhaled 1 ml (250 mg ipratronium bromide and 500 mcg phenoterol hydrobromide) berodual by means of nebulizer. 68% of the examinees responded with obstruction of the distal part of the respiratory tree. RS causes partially reversible defects in permeability, primarily at the level of small bronchi. Berodual-induced changes in the curve flow-volume in RS differed from those in CNSPD patients by the absence of a rise in the exhalation power. Lofgren's syndrome deteriorated reversibility of bronchial permeability defects in RS patients. Smoking effects on bronchial permeability and reversibility of relevant defects in RS patients were insignificant. Pathogenesis of reversible obstruction in sarcoidosis demands further studies.
PMID: 11759402 [PubMed - indexed for MEDLINE]
31. Guryleva M.E., Vizel' A.A., Krasnoperov F.T. History of phthisiology teaching at the Kazan Medical University // Probl. Tuberk., 2001. N 5. P. 6062.
Publication Types: Historical Article
PMID: 11588971 [PubMed - indexed for MEDLINE]
32. Vizel' A.A., Iaushev M.F. Technical aids in teaching phthisiopulmonology // Probl. Tuberk., 2001. N 6. P.44 46.
PMID: 11641961 [PubMed - indexed for MEDLINE]
33. Vizel' A.A. The use of global internet in a phthysio-pulmonologist's practice // Probl. Tuberk., 2002. N 2. P.55-57.
PMID: 11899812 [PubMed - indexed for MEDLINE]
34. Vizel' A.A., Dmitriev E.G., Bulashova O.V., Islamova L.V., Dmitriev O.Iu., Fakhrutdinov M.M., Drent M. A case of pulmonary histiocytosis X // Probl. Tuberk., 2002. N 2. P.45-47.
PMID: 11899808 [PubMed - indexed for MEDLINE]
35. Guryleva M.E., Vizel' A.A., Khuzieva L.V. Assessment of life quality in patients with respiratory diseases // Probl. Tuberk. 2002. N 5. P.5561.
PMID: 12164125 [PubMed - indexed for MEDLINE]
36. Gilmanov A.A., Vizel A.A., Khamitov R.F., Sergeev V.A., Bunatian A.A., Sorockina M.Sh., Vizel E.A. Role of protocols and formularity in pneumonia treatment // 33rd IUATLD World Conference on lung health & 3rd Stop tb dots expansion working group meeting. Montreal, Canada, 2002.
37. Vizel A.A., Khabibullin K.A., Khabibullina R.T., Miftachutdinova R.T. Relationship between cholinergic tone and gastroduodenal ulcer in COPD // LInternista. 2002. N 10. P. 148152.
SUMMARY. Study objective: Cholinergic tone plays a major role in bronchoconstriction of patients with chronic obstructive pulmonary disease (COPD). A simultaneous active gastroduodenal ulcer (AGDU) may be ac-compained with a raised cholonergic tone (ChT) and thus brochoconstriction. Ipratropium Bromide (IB) should be effective to reduce bronchoconstriction of such patients. The aim of this research is to reveal a degree of participation of raised ChT in the formation of bronchoconstriction and to learn how to adjust it. Design: Comparative research of parallel groups. Setting: The Faculty of Phtysiopulmonology of Kazan Medical University, the Department of Functional Diagnostics, and the Department of Gastroenterology, Hospital N11, Kazan, Russian Federation. Subjects: 30 patients with COPD with GDU; 21 COPD patients without GDU; 19patients with GDU without COPD; 18 healthy patients. Interventions: The comparison of effects of the inhalation of MDI IB (40 meg) between groups. Measurements: The parameters of airways' patency and the heart rate variability were measured before and 60 min after IB inhalation. Results: The reduction of bronchoconstriction of the COPD patients in combination with active gastroduodenal ulcer disease after IB inhalations is more effective in comparison with other groups. Conclusion: The raised cholinergic tone and ''pulmonary component'' participate in the formation of bronchoconstriction of the patients with COPD and AGDU disease in equal degree. The inhalation of 40 meg ipratropium bromide considerably increases airway patency in the patients with COPD and AGDU and reduces the raised cholinergic tone down to vegetative balance. (Internista 2002; 10:148-152)
38. Gil'manov A.A., Vizel' A.A., Malysheva I.Iu., Sorokina M.Sh., Sadykova R.S., Buniatian A.A. Analysis of the efficiency of treatment and causes of death in nosocomial pneumonia in the Republic of Tatarstan // Probl Tuberk. 2002. N 7. P. 26-30. Russian.
A comprehensive study was undertaken to examine morbidity due nosocomial pneumonia. An epidemiological survey demonstrated a growth in morbidity and mortality from this disease among the adult population of the Republic of Tatarstan. Pharmacological and epidemiological survey indicated that antibacterial therapy was in conformity with the federal protocols in 43.9% of cases, revealed the optimization of the use of antibacterial agents after introduction of the federal standards. At the same time the low social status of patients dying from pneumonia was accompanied by their appeal for medical aid, which leads to late hospitalization and untimely intensive therapy.
PMID: 12561638 [PubMed - indexed for MEDLINE]
39. Vizel' A.A., Gil'manov A.A., Samerkhanova A.E., Gizatullina E.D., Buniatin A.A. Comparison of acute bronchiolytic effect of inhaling solutions of berodual vs salgim using a nebulizer in patients with chronic obstructive bronchitis and bronchial asthma // Ter. Arkh. 2002. Vol.74. N 8. P.49-52.
AIM: Comparison of acute response to nebulizer inhalation of therapeutic doses of combined broncholitic berodual and domestic bronchoselective adrenomimetic salgim in patients with bronchial asthma (BA) and chronic obstructive bronchitis (COB). MATERIAL AND METHODS: The trial included 17 COB and 15 BA patients who for two consecutive days inhaled berodual and salgim solutions. Before and after the inhalations, subjective condition of the patients and parameters of the forced expiration were recorded. The sequence of the solutions use was determined randomly. RESULTS: Nebulizer inhalations of berodual and salgim relieved respiration subjectively in 83.9 and 93.5% patients, respectively. Significant bronchodilation was registered 30 min after inhalation of each of the solutions both in BA and COB. Berodual caused no side effects, salgim provoked short-term cough in 6(19.4%) patients. CONCLUSION: Nebulizer therapy of berodual or salgim is clinically and cost effective in moderate and severe obstruction in BA and COB patients.
Publication Types: Clinical Trial Randomized Controlled Trial
PMID: 12360595 [PubMed - indexed for MEDLINE]
40. Vizel AA, Islamova LV, Guryleva ME, Amirov NB, Dmitriev EG, Bondarev AV,Nasretdinova GR Comparative evaluation of the effects of different
bronchodilators in sarcoidosis // Probl Tuberk. 2003. N.6. P.33-36.
(Comparative evaluation of effects of various bronchodilators in sarcoidosis)
The investigation was undertaken to compare three bronchodilators on patients with respiratory sarcoidosis. Ninety patients (66 females and 24 males) with intrathoracic sarcoidosis were examined. X-ray stages I, II, III, and IV were seen in 48.9, 46.7, 3.3, and 1.1%, respectively. A flow-volume curve was recorded on a Masterscreen Pnevmo apparatus (Erich Jaeger) before and after inhalations of salbutamol (200 micrograms, a flask), ipratropium bromide (40 micrograms, a flask), and 1 ml of berodual solution through a Boreal nebulizer. The mean baseline values of forced expiration were normal, except for MOS75 (51.0 +/- 1.3% of the normal values). After salbutamol, the increment of MOS75 was higher than that after ipratropium (20.7 +/- 3.1% and 12.3 +/- 2.3%, respectively, p < 0.05); however, after berodual nebulization, the increase in MOS50 was greater than that after inhalation of ipratropium (17.2 +/- 1.9% versus 10.7 +/- 1.6%, p < 0.05) or salbutamol (10.1 +/- 6%, p < 0.01). The changes in these parameters in smokers and nonsmokers were similar. The one-month or more inhalation of budesonide (benacort) potentiated the bronchodilating action of salbutamol on all the parameters of forced expiration, but failed to affect the effect of ipratropium and berodual. Prednisolone did not affect the effects of bronchodilators. A combination of beta 2 agonist and inhaled steroid may be effective in intrathoracic sarcoidosis with the bronchial obstruction syndrome. The mechanism of varying action of the drugs having different mechanisms of action requires further investigations.
PMID: 12918239 [PubMed - indexed for MEDLINE]
41. Guryleva M.E., Vizel' E.A., Kazakov I.M., Domracheva O.V., Tiurina N.P., Vizel' A.A. Sarcoidosis as seen by a patient: results of questionnaire survey // Probl Tuberk. 2003. N 6. P.10-13.
[Article in Russian]
Two hundred patients with sarcoidosis were interviewed by a questionnaire in the global Internet. For comparison, the same questionnaire was used in the interviews of 60 patients in Kazan. Among international responders, patients from the USA were prevalent. The age of 30-39 years was predominant in both groups, females were three fourths. Predominance of these or those social groups was not established. At the same time, analysis of professions revealed a large number of medical workers in both Kazan (11.7%) and abroad (17%). In global practice the diagnosis of sarcoidosis is much more frequently histologically verified though in Russia the likely diagnosis of sarcoidosis is much earlier established during the patient's visit to a doctor. The basic drugs for its therapy are glucocorticoids. Inhaled steroids are used relatively rarely. Only Russia is marked by the use of antituberculous agents. The authors note that the Internet may be a field for research activities in medical science.
PMID: 12918232 [PubMed - indexed for MEDLINE]
42. Vizel A.A., Nizamov I.G., Gilmanov A.A., Hasanov R.Sh., Gouryleva M.E., Vizel E.A. Diagnosis and treatment of sarcoidosis in Tatarstan Republic: the influence of ATS/ERS/WASOG statement on sarcoidosis // Europ.Resp.J. 2003. Vol.22. Suppl.45. Ref. N 1568. P. 234S.
In 1999 the ATS/ERS/WASOG Statement on sarcoidosis was published. Before that 90% of sarcoidosis cases in Tatarstan Republic were being revealed and treated in TB-dispensaries. We began the application of main positions of the Statement in 1999.
New approach include the exclusion of tuberculosis in TB-dispensaries, complete examination in the noninfectious diagnostic center, transbronchial or videoassist thoracoscopic biopsy in the general all-republic clinic or oncological dispensary, long-term outpatient observation and treatment at the Kazan Medical University specialist.
296 patients were observed. The new method resulted in several changes. We excluded trial treatment with antituberculosis medicines, excluded hospitalization to the TB-dispensaries. We met hystologically verified cases of skin sarcoidosis, revealed 3 cases of cardiac sarcoidosis with the help of Holters monitoring, 1 case of central nervous system sarcoidosis, in 70% of cases in the first 6 months patients were observed without any treatment.
ATS/ERS/WASOG Statement on sarcoidosis may become a basis in making the local standards of diagnostics and treatment of sarcoidosis in our Republic.
43. Gouryleva M.E., Vizel A.A., Gilyazutdinov I.A., Vizel E.A. The quality of life comparative research of sarcoidosis patients and patients with lung cancer // Europ.Resp.J. 2003. Vol.22. Suppl.45. Ref. N 1674. P. 254S.
In the aim of comparative investigation of quality of life (QOL) with the help of WHOQOL-100 questionnaire there were examined 66 patients with lung sarcoidosis (mean age 42.05 ± 1.26 y.o.) and 26 patients with lung cancer (44.12 ± 0.9 y.o.) before operation.
During comparing sarcoidosis patients and lung cancer patients QOL there were revealed a great worse QOL of patients with sarcoidosis in all scales of the questionnaire. Main differences were in general QOL, in scale of psychological health, social relations and environment (π<0,001). Sarcoidosis patients slept worse, were less active and mobile, had a greater dependence on medicines and medication, had worse relations with people, less opportunities of social support, had more difficulties in sexual life, it was much more difficult to them to get a qualified medical help (π<0,001). Sarcoidosis patients had less opportunities of studying, worse memory, felt much more negative and less positive emotions (π< 0,001). They were more frequently not satisfied with environment, had less opportunities of spending leisure and having rest.
Thus, a conclusion can be made, that QOL of lung sarcoidosis patients is for certain worse then QOL of lung cancer patients, which were taken as a negative control group. The future investigations are needed.
44. Gilmanov A.A., Vizel A.A., Bunyatyan A.A., Khamitov R.F., Sergeev V.A. Estimation of quality of medical care for patients with bronchial asthma in the period of introducing treatment protocols in Tatarstan Republic // Kazan Medical Journal. - 2003. - N 4 -- P. 303-307.
Comparative analysis of diagnosis and treatment of patients with bronchial asthma at outpatient and hospital treatment stages before and after introducing standards of diagnosis and treatment of respiratory diseases was carried out. Qualified medical care for patients with bronchial asthma in Tatarstan Pepublic does not completely correspond to existing federal standards. Introduction of pulmonologic standards of diagnosis and treatment resulted in improvement of medical care for patients with bronchial asthma, however, acute necessity of wider use of pulmonary function tests in the central regional Hospitals as well as in large hospitals of Kazan was found.
http://www.kcn.ru/tat_en/science/kazmed/04.2003.htm#k22
45. Vizel A.A., Samerkhanova A.E., Vizel I.Yu., Khabibullin K.A., Vizel E.A. Results of prolonged monitoring of pulmonary function test in patients with chronic obstructive pulmonary disease and bronchial asthma // Kazan Medical Journal. - 2003. - N 5 -- P. 349-351.
Parameters of the flow - volume curve of forced expiration are registered during three years in 60 patients with bronchial asthma and 98 patients with chronic obstructive pulmonary disease taking treatment according to GINA and GOLD recommendations. Reliable improvement of parameters has been noted during the first six months of basic and symptomatic therapy. A decrease of bronchial permeability indices has been significantly retarded during three years. Incomplete parallelism of variations of peak expiration flow and volume of forced expiration per one second in patients with bronchial asthma should be noted. Peak expiration flow is preserving for longer time and it is considered to be the most important index in self-control of asthma, should be noted.
http://www.kcn.ru/tat_en/science/kazmed/05.2003.htm#k6
46. Vizel' A.A., Guryleva M.E., Vizel' E.A., Nasretdinova G.P. The role of tumor necrosis factor in pathogenesis and treatment of sarcoidosis // Klin Med (Mosk). - 2003. - Vol. 81. - N 9. - P.4-8. ( Publication Types: Review Review Literature. PMID: 14598582. PubMed - indexed for MEDLINE).
47. Vizel A.A., Islamova L.V., Amirov N.B., Mingaleev F.A., Kataev O.G., Potanin V.P., Guryleva M.E., Nasretdinova G.R., Valitov F.M. Estimation of effect of various treatment regimes on clinical, radiological and functional parameters in patients with intrathoracic sarcoidosis // Kazan Medical Journal 2004 N2 90-95
Dynamics of clinical, radiological and functional parameters is estimated in patients with sarcoidosis on various treatment. Treatment regimes included prednisolone, budesonide, methotrexat, pentoxiphilin, viamin E and observation without treatment. As a whole positive dynamics of basic studied indices was noted. The advantage of any treatment regimes was not established.
http://www.kcn.ru/tat_en/science/kazmed/02.2004.htm#k3
48. Vizel' AA, Amirov NB, Mingaleev FA, Islamova LV, Akhunova SIu, Kataev OG,
Dmitriev OIu, Amirova RN. [Specific features of cardiorespiratory system in patients with intrathoracic sarcoidosis // Probl Tuberk Bolezn Legk. 2004;(2):35-8. [Article in Russian]
A hundred thirty eight patients with pulmonary sarcoidosis were examined for the status of the respiratory and cardiovascular systems. There is a trend for external respiratory parameters to decrease as the X-ray stage increases (by 30-50% in Stage IV). The revealed cardiovascular changes in patients with different X-ray stages did not differ significantly and there was no clear correlation with the activity of a process and external respiratory parameters. The only hemodynamic indicator clearly associated with the status of the lung was pulmonary hypertension. The involvement of the heart was ascertained not to depend on the stage and activity of sarcoidosis and on the degree of respiratory disorders clearly, which requires cardiovascular monitoring in all patients with sarcoidosis.
PMID: 15137127 [PubMed - indexed for MEDLINE]
49. Iaushev M.F., Boichuk S.V., Vizel' A.A., Sadykova G.N. A comparative study of lymphocytic apoptosis and ventilation disorders in patients with pulmonary tuberculosis // Probl Tuberk Bolezn Legk. 2004(5):10-3. [Article in Russian]
Due to the increasing interest in studies of apoptosis (programmed cell death) in the pathogenesis of many diseases and to the emergence of data on the direct impact of apoptotic disorders on the course of bronchial asthma and the magnitude of the obstructive syndrome, this study was undertaken to investigate apoptosis in patients with new-onset pulmonary tuberculosis who had varying bronchial obstructive syndrome. Twenty-eight patients with new-onset tuberculosis, including 25 (89.3%), 2(7.1%), 1(3.6%) patients with infiltrative, disseminated, and fibrocavernous pulmonary tuberculosis, respectively, were examined. The study of external respiratory function included spirometry, determination of the flow-volume of forced expiration, body plethysmography, examination of lung elasticity by esophageal probing. The mechanisms of spontaneous apoptosis of peripheral lymphocytes from donors and patients with pulmonary tuberculosis were studied. The apoptosis was evaluated in dynamics by some parameters: the change of the mitochondrial potential (MP), the level of phosphatidyl serine, as well as DNA fragmentation by flow cytofluorometry. The results have indicated that there are significant signs of impaired peripheral lymphocytic apoptosis. Examining external respiratory function indicated that the bronchial obstruction syndrome was mild in 7 (25%) patients, moderate in 11 (39.3%), and severe in 5 (17.9%), absent in 5 (17.9%). Mild restrictive disorders were detected in 11 (39.3%) patients. The factor associating the degree of obstruction, with the count of MC540(+)- and MC540-DiOC6(+)-lymphocytes, i.e., with the count of lymphocytes with cellular membranous changes and with the decreased MP, which are one of the most significant signs of apoptosis. Thus, there is a negative correlation of the parameters of apoptosis of peripheral lymphocytes from patients with tuberculosis with those of ventilation obstruction disorders, which suggests that impaired apoptosis might be involved in the development of bronchial obstruction.
PMID: 15230197 [PubMed - indexed for MEDLINE]
50. Vizel' AA, Stepanov AIu, Guryleva ME, Nasretdinova GR. Sarcoidosis and pregnancy: data from scientific publications and a clinical case. - Probl Tuberk Bolezn Legk. 2004(9):50-3.
The paper analyzes the literature on sarcoidosis and pregnancy, available from the MedLine bases and Russian journals. It also presents a clinical case of sarcoidosis developed and recurred in a female after the first and repeated pregnancy. It is concluded that pregnancy in sarcoidosis may be preserved in most cases. Life-threatening rhythm and conduction disturbances, significant failure of the organs and systems afflicted by sarcoidosis, as well as female genital sarcoidosis may be a reason for deciding whether pregnancy should be preserved.
PMID: 15532470 [PubMed - indexed for MEDLINE]
51. Ziganshina L., Vizel A., Squire S. Fluoroquinolones for treating tuberculosis // Cochrane Database Syst. Rev. - 2005. Jul 20;3:CD004795. The Cochrane Database of Systematic Reviews 2005, Issue 3. Art. No.: CD004795. DOI: 10.1002/14651858.CD004795.pub2.
BACKGROUND: Fluoroquinolones are sometimes used to treat multiple-drug-resistant and drug-sensitive tuberculosis. The effects of fluoroquinolones in tuberculosis regimens need to be assessed. OBJECTIVES: To assess fluoroquinolones as additional or substitute components to antituberculous drug regimens for drug-sensitive and drug-resistant tuberculosis. SEARCH STRATEGY: We searched the Cochrane Infectious Diseases Group Specialized Register (April 2005), CENTRAL (The Cochrane Library Issue 1, 2005), MEDLINE (1966 to April 2005), EMBASE (1974 to April 2005), LILACS (1982 to April 2005), Science Citation Index (1940 to April 2005), and Russian database (1988 to April 2005). We also scanned reference lists of all identified studies and contacted researchers. SELECTION CRITERIA: Randomized controlled trials of antituberculous regimens containing fluoroquinolones in people diagnosed with bacteriologically positive (sputum smear or culture) pulmonary tuberculosis. DATA COLLECTION AND ANALYSIS: Two authors independently applied inclusion criteria, assessed methodological quality, and extracted data. We used relative risk (RR) for dichotomous data, weighted mean difference (WMD) for continuous data (both with 95% confidence intervals (CI)), and the random-effects model if we detected heterogeneity and appropriate to combine data. MAIN RESULTS: Ten trials (1178 participants) met the inclusion criteria. No statistically significant difference was found in trials substituting ciprofloxacin or ofloxacin for first-line drugs in relation to cure (89 participants, 2 trials), treatment failure (388 participants, 3 trials), or clinical or radiological improvement (216 participants, 2 trials). Substituting ciprofloxacin into first-line regimens in drug-sensitive tuberculosis led to a higher incidence of relapse (RR 7.17, 95% CI 1.33 to 38.58; 384 participants, 3 trials) and longer time to sputum culture conversion (WMD 0.50 months, 95% CI 0.18 to 0.82; 168 participants, 1 trial), although this was confined to HIV-positive participants. Adding or substituting levofloxacin to basic regimens in drug-resistant areas had no effect. A comparison of sparfloxacin versus ofloxacin added to regimens showed no statistically significant difference in cure (184 participants, 2 trials), treatment failure (149 participants, 2 trials), or total number of adverse events (253 participants, 3 trials). AUTHORS' CONCLUSIONS: Only ciprofloxacin, ofloxacin, levofloxacin, and sparfloxacin have been tested in randomized controlled trials for treating tuberculosis. We cannot recommend ciprofloxacin in treating tuberculosis. Trials of newer fluoroquinolones for treating tuberculosis are needed. No difference has been demonstrated between sparfloxacin and ofloxacin in drug-resistant tuberculosis.
PMID: 16034951 [PubMed - as supplied by publisher]
52. Vizel' AA, Vizel' IIu, Vizel' EA. Comparison of acute bronchodilator tests in patients with chronic obstructive lung disease and bronchial asthma. Probl Tuberk Bolezn Legk. 2005;(7):40-4. [Article in Russian]
Three hundred and thirty-five patients with bronchial asthma (BA) and 534 patients with chronic obstructive lung disease (COLD) were examined. Before and after tests using salbutamol, phenoterol, ipratropium bromide and a fixed combination of phenoterol and ipratropium bromide, the forced expiratory flow-volume curve was recorded in the patients on each visit (1008 and 1398 visits of patients with BA and COLD, respectively). The study was controlled open-labeled, and prospective. All the bronchodilators were found to be effective in both BA and COLD. However, in asthmatic patients without (less than 4%) and with (more than 5%) eosinophilia, the increase in forced expiratory volume per second (FEV1) was 23.7+/-22.1% and 16.0+/-14.6% of the baseline values, respectively (p < 0.05). Among these patients with ESR of less than 100 mm/hour, the increase in FEV1 was significantly higher--21.7+/-19.7% than in those who had ERS more than 15 mm/hour and this was 13.8+/-17.9% of the baseline values (p < 0.05). Among asthmatic patients, more than 15% increases in FEV1 after administration of bronchodilators were noted in 48% of the patients untreated with inhaled corticosteroids (ICS) and in 61% of the ICS-treated patients (chi2 = 6.55; d.f. = 1; p = 0.01). Among ICS-treated and untreated patients with BA, the mean increase in FEV1 was 24.4+/-22.5% and 19.6+/-22.0% of the baseline values, respectively (p < 0.05). In COLD patients, these differences were absent. It has been concluded that eosinophilic inflammation typical of BA decreases the effect of bronchodilators in BA and that inhaled steroids improve it.
PMID: 16130428 [PubMed - indexed for MEDLINE]
53. Vizel' AA, Nasretdinova GR, Islamova LV, Vizel' EA. Evaluation of the efficiency of various treatment regimens for patients with newly-detected sarcoidosis in the Republic of Tatarstan // Probl Tuberk Bolezn Legk. 2006;(4):19-23. [Article in Russian]
The natural history of sarcoidosis was analyzed in 279 patients with its history of as long as 2 years among the 832 with this disease registered in the Republic of Tatarstan in 1999 to 2002. The patients were divided into 3 groups: (1) 79 (28.3%) receiving systemic glucocorticosteroids (SGS); (2) 146 (52.3%) patients having therapy without SGS; (3) 54 (19.3%) patients receiving no drug therapy, but they were followed up by a physician. There was no strong evidence for that it was expedient to use prednisolone in most of patients. Prednisolone exerted a significant effect on clinical manifestations, laboratory values, and radiation pattern in patients with sarcoidosis, but more commonly (28.9%) led to its relapses than alternative treatment and active follow-up. Patients treated with prednisolone and other drugs and those untreated showed no significant differences in the frequency of cases of a worse X-ray pattern during 28 years. It is advisable to follow an active observation policy in patients having a stable course of sarcoidosis, by restricting indications for the use of prednisolone in those who have apparently progressive or threatening extrapulmonary manifestations of the disease (heart, nervous system, eyes).
PMID: 16813054 [PubMed - indexed for MEDLINE]
54. Vizel' A.A., Vizel' I.Iu., Vizel' E.A. Individual application of a personal computer in practice of the pulmonologist: the experience with 12-year monitoring // Ter Arkh. 2007;79(3):55-7. Russian. PMID: 17526199 [PubMed - indexed for MEDLINE]